Dusp2^tm1Yxy
Targeted Allele Detail

Summary

• Symbol: Dusp2^tm1Yxy
• Name: dual specificity phosphatase 2; targeted mutation 1, Yuxin Yin
• MGI ID: MGI:6147669
• Gene: Dusp2 Location: Chr2:127178079-127180296 bp, + strand Genetic Position: Chr2, 61.93 cM
• Alliance: Dusp2^tm1Yxy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:233916
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 to 4 were replaced with a neomycin resistance cassette flanked by loxP sites via homologous recombination. Quantitative RT-PCR and immunoblot analysis showed undetectable expression in lymphoid homogenates. (J:233916)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dusp2 Mutation: 12 strains or lines available

References

• Original: J:233916 Lu D, et al., The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation. Nat Immunol. 2015 Dec;16(12):1263-73
• All: 1 reference(s)