Cdh9^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Cdh9^{tm1b(KOMP)Wtsi}
• Name: cadherin 9; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6147663
• Gene: Cdh9 Location: Chr15:16728842-16857180 bp, + strand Genetic Position: Chr15, 7.91 cM
• Alliance: Cdh9^{tm1b(KOMP)Wtsi} page
• IMPC: Cdh9 gene page

Mutation origin

• Mutant Cell Line: EPD0837_1_F03
• Germline Transmission: Earliest citation of germline transmission: J:214586
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The L1L2_Bact_P cassette was inserted at position 16830542 of Chromosome 15 upstream of exon 5 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of exon 5 at position 16831438. Exon 5 is thus flanked by loxP sites. After subsequent cre expression this reporter knockout allele was created. (J:214586)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdh9 Mutation: 46 strains or lines available

References

• Original: J:214586 Duan X, et al., Type II cadherins guide assembly of a direction-selective retinal circuit. Cell. 2014 Aug 14;158(4):793-807
• All: 4 reference(s)