Fcgr2b^del
Spontaneous Allele Detail

Summary

• Symbol: Fcgr2b^del
• Name: Fc receptor, IgG, low affinity IIb; autoimmune Fcgr2 promoter haplotype
• MGI ID: MGI:6147620
• Synonyms: AIH, autoimmune Fcgr2 promoter haplotype, NZB-type fcgr2b allele, promoter region deletion haplotype
• Gene: Fcgr2b Location: Chr1:170786186-170804116 bp, - strand Genetic Position: Chr1, 78.02 cM
• Alliance: Fcgr2b^del page

Mutation origin

• Strain of Origin: multiple strains

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutations: Intragenic deletion, Nucleotide substitutions
• Mutation details: The Fcgr2b gene promoter in a set of autoimmune-prone mice was shown to be disrupted by a a 13 bp deletion interrupting two putative transcription factor binding sites, an AP4 site and an S box. Strains and strain families that carry this mutations include NZB, BXSB, SB/Le, MRL, NOD and 129. In addition, NZB has seven As from 247 to 242 instead of 6 (NZW) or 5 (CON); NOD has a T at 21 (as does NZW) instead of a C. (J:79651)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fcgr2b Mutation: 49 strains or lines available

References

• Original: J:79651 Pritchard NR, et al., Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcgammaRII. Curr Biol. 2000 Feb 24;10(4):227-30
• All: 3 reference(s)