Mir486^em1Mtm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mir486^em1Mtm
• Name: microRNA 486; endonuclease-mediated mutation 1, Micheal McManus
• MGI ID: MGI:6147598
• Gene: Mir486 Location: Chr8:23632571-23632698 bp, + strand Genetic Position: Chr8, 11.42 cM
• Alliance: Mir486^em1Mtm page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting produced an 85 bp deletion. Northern blot analysis confirmed the absence of RNA production. (J:257557)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mir486 Mutation: 5 strains or lines available

References

• Original: J:257557 Jee D, et al., Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals. Mol Cell. 2018 Jan 18;69(2):265-278.e6
• All: 2 reference(s)