Gt(ROSA)26Sor^{tm1.1(tetO-Mir128-2)Ygw}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(tetO-Mir128-2)Ygw}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Yigang Wang
• MGI ID: MGI:6144247
• Synonyms: miR-128^TetRE
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(tetO-Mir128-2)Ygw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257896
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(tetO-Mir128-2)Ygw} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mir128-2 (MGI:3618709)

• Mutation details: The Mir128-2 (Mir12-3p) gene under the control of the tetO-minimum promoter and a loxP-flanked neomycin resistance cassette upstream of the promoter were knocked-into the locus. Cre-mediated recombination removed the neomycin cassette. (J:257896)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:257896 Huang W, et al., Loss of microRNA-128 promotes cardiomyocyte proliferation and heart regeneration. Nat Commun. 2018 Feb 16;9(1):700
• All: 1 reference(s)