Igf2^tm1.1Thor
Targeted Allele Detail

Summary

• Symbol: Igf2^tm1.1Thor
• Name: insulin-like growth factor 2; targeted mutation 1.1, Bernard Thorens
• MGI ID: MGI:6144126
• Synonyms: Igf2^lox
• Gene: Igf2 Location: Chr7:142204503-142220553 bp, - strand Genetic Position: Chr7, 87.99 cM
• Alliance: Igf2^tm1.1Thor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246167
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was flanked by loxP sites. An FRT-flanked neomycin selection cassette was inserted downstream of exon 4 but before the second loxP site. Flp-mediated recombination removed the neomycin cassette. (J:246167)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Igf2 Mutation: 29 strains or lines available

References

• Original: J:246167 Modi H, et al., Autocrine Action of IGF2 Regulates Adult beta-Cell Mass and Function. Diabetes. 2015 Dec;64(12):4148-57
• All: 2 reference(s)