Snx22^tm1.1Kmm
Targeted Allele Detail

Summary

• Symbol: Snx22^tm1.1Kmm
• Name: sorting nexin 22; targeted mutation 1.1, Kenneth Murphy
• MGI ID: MGI:6143954
• Synonyms: Snx22^GFP
• Gene: Snx22 Location: Chr9:65972458-65977001 bp, - strand Genetic Position: Chr9, 35.69 cM
• Alliance: Snx22^tm1.1Kmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257973
• Parent Cell Line: EDJ22 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting vector is designed to replace exons 1-3 of the gene with an enhanced green fluorescent protein (EGFP) sequence followed by a loxP-flanked neomycin selection (neo) cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:257973)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Snx22 Mutation: 12 strains or lines available

References

• Original: J:257973 Brahler S, et al., Opposing Roles of Dendritic Cell Subsets in Experimental GN. J Am Soc Nephrol. 2018 Jan;29(1):138-154
• All: 5 reference(s)