Mbl2^{em1(IMPC)Wtsi}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mbl2^{em1(IMPC)Wtsi}
• Name: mannose-binding lectin (protein C) 2; endonuclease-mediated mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:6140211
• Gene: Mbl2 Location: Chr19:30210342-30217087 bp, + strand Genetic Position: Chr19, 25.14 cM
• Alliance: Mbl2^{em1(IMPC)Wtsi} page
• IMPC: Mbl2 gene page

Mutation origin

• Strain of Origin: C57BL/6N
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated at Wellcome Sanger Institute using Cas9 and guides with spacer sequences ACTTCCTAAATGCACCGCTT, AGATGTACTTCCTTACAATG, GCCCAGTCTCAGGTATTAAA, and GTGGCGTCTTTTTTCAGAGG that targeted exon(s) ENSMUSE00000145658.2 ENSMUSE00000370957.8. This resulted in deletion(s) of 3 bp (location: Chr19:30217217-30217219; GRCm39), 1471 bp (location: Chr19:30215739-30217209; GRCm39). This description was generated automatically. Additional molecular information including FASTA sequence support for this allele can be found here: (IMPC Gene page) and viewed in a genome context here: (IMPC Genome Browser). (J:384794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mbl2 Mutation: 20 strains or lines available

References

• Original: J:237616 MGI and IMPC, MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). MGI Direct Data Submission. 2017-8
• All: 3 reference(s)