Tg(Myh6-PDK4)1Sakl
Transgene Detail
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Symbol: |
Tg(Myh6-PDK4)1Sakl |
Name: |
transgene insertion 1, Steven A Kliewer |
MGI ID: |
MGI:6140095 |
Synonyms: |
alpha-MHC-PDK4, MHC-PDK4, Tg(Myh6-Pdk4,GH1)1Sakl |
Transgene: |
Tg(Myh6-PDK4)1Sakl Location: unknown
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Alliance: |
Tg(Myh6-PDK4)1Sakl page
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Myh6-PDK4)1Sakl expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
PDK4 (5166) |
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Mutation details: The alpha-MHC-PDK4 transgene consists of a 5.5-kb segment of the myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6; also called alpha-MHC) gene promoter, a 1.3-kb human pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4) cDNA, and the 0.6-kb human growth hormone gene polyadenylation signal. Two independent lines were established.
(J:132373)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:132373 Zhao G, et al., Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H936-43 |
All: |
2 reference(s) |
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