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Tg(Myh6-PDK4)1Sakl
Transgene Detail
Summary
Symbol: Tg(Myh6-PDK4)1Sakl
Name: transgene insertion 1, Steven A Kliewer
MGI ID: MGI:6140095
Synonyms: alpha-MHC-PDK4, MHC-PDK4, Tg(Myh6-Pdk4,GH1)1Sakl
Transgene: Tg(Myh6-PDK4)1Sakl  Location: unknown  
Alliance: Tg(Myh6-PDK4)1Sakl page
Transgene
origin
Strain of Origin:  (C57BL/6 x C3H)F1
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-PDK4)1Sakl expresses 1 gene
 
Mutation detailsThe alpha-MHC-PDK4 transgene consists of a 5.5-kb segment of the myosin, heavy polypeptide 6, cardiac muscle, alpha (Myh6; also called alpha-MHC) gene promoter, a 1.3-kb human pyruvate dehydrogenase kinase, isoenzyme 4 (PDK4) cDNA, and the 0.6-kb human growth hormone gene polyadenylation signal. Two independent lines were established. (J:132373)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:132373 Zhao G, et al., Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2008 Feb;294(2):H936-43
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory