Tg(Prnp-PLS3)14Ahmb
Transgene Detail

Summary

• Symbol: Tg(Prnp-PLS3)14Ahmb
• Name: transgene insertion 14, Arthur H M Burghes
• MGI ID: MGI:6121381
• Synonyms: PrP:PLS3
• Transgene: Tg(Prnp-PLS3)14Ahmb Location: unknown
• Alliance: Tg(Prnp-PLS3)14Ahmb page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prnp-PLS3)14Ahmb expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PLS3 (5358)

  Pls3	(MGI:104807)

• Mutation details: The transgenic construct contains the regulatory sequences from mouse prion protein gene (the promoter region, exon 1, intron 1 and part of exon 2) followed by a cDNA encoding the human plastin 3 protein and two SV40 polyA signals. (J:238311)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:238311 McGovern VL, et al., Plastin 3 Expression Does Not Modify Spinal Muscular Atrophy Severity in the 7 SMA Mouse. PLoS One. 2015;10(7):e0132364
• All: 1 reference(s)