Phb1^tm1.1Sclu
Targeted Allele Detail

Summary

• Symbol: Phb1^tm1.1Sclu
• Name: prohibitin 1; targeted mutation 1.1, Shelly C Lu
• MGI ID: MGI:6121123
• Synonyms: Phb1^loxP
• Gene: Phb1 Location: Chr11:95557783-95571599 bp, + strand Genetic Position: Chr11, 59.01 cM, cytoband D
• Alliance: Phb1^tm1.1Sclu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238687
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites. A FRT-flanked neomycin cassette was inserted upstream of the floxed exon 2. Flp-mediated recombination removed the neomycin cassette. (J:238687)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phb1 Mutation: 22 strains or lines available

References

• Original: J:238687 Ko KS, et al., Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. Hepatology. 2010 Dec;52(6):2096-108
• All: 5 reference(s)