Nlrx1^tm1.1Seg
Targeted Allele Detail

Summary

• Symbol: Nlrx1^tm1.1Seg
• Name: NLR family member X1; targeted mutation 1.1, Stephen E Girardin
• MGI ID: MGI:6121025
• Gene: Nlrx1 Location: Chr9:44164014-44179896 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Nlrx1^tm1.1Seg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257411
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT-flanked phosphoglycerate kinase-neomycin (PGK-Neo) selection cassette were inserted upstream of exon 3 and a second loxP site downstream of exon 3. Cre-mediated recombination removed the PGK-Neo and exon 3. Western blot analysis confirmed absence of protein in MEFs and bone marrow derived macrophages. (J:257411)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrx1 Mutation: 39 strains or lines available

References

• Original: J:257411 Soares F, et al., NLRX1 does not inhibit MAVS-dependent antiviral signalling. Innate Immun. 2013;19(4):438-48
• All: 8 reference(s)