Dnpep^em1Dlp
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dnpep^em1Dlp
• Name: aspartyl aminopeptidase; endonuclease-mediated mutation 1, Eric Delpire
• MGI ID: MGI:6120903
• Gene: Dnpep Location: Chr1:75285209-75294298 bp, - strand Genetic Position: Chr1, 38.71 cM
• Alliance: Dnpep^em1Dlp page

Mutation origin

• Strain of Origin: C57BL/6 x DBA/2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A T-to-A mutation substituting codon Lys21 into a stop codon was introduced into exon 2 using CRISPR/Cas9 technology. (J:256298)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dnpep Mutation: 35 strains or lines available

References

• Original: J:256298 Koumangoye R, et al., DNPEP is not the only peptidase that produces SPAK fragments in kidney. Physiol Rep. 2017 Nov;5(21)
• All: 2 reference(s)