Serpinb5^tm1.2Shsh
Targeted Allele Detail

Summary

• Symbol: Serpinb5^tm1.2Shsh
• Name: serine (or cysteine) peptidase inhibitor, clade B, member 5; targeted mutation 1.2, Shijie Sheng
• MGI ID: MGI:6119756
• Synonyms: Maspin^Δ, Maspin^Delta
• Gene: Serpinb5 Location: Chr1:106788905-106811078 bp, + strand Genetic Position: Chr1, 50.34 cM
• Alliance: Serpinb5^tm1.2Shsh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:239395
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct contained loxP sites flanking exon 4 and a FRT-flanked PGK-neomycin selection cassette inserted between exons 3 and 4. Flp-mediated recombination removed the neomycin cassette. Cre-mediated recombination removed exon 4. In the absence of exon 4, the protein is not expected to fold properly and should be unstable. (J:239395)

Tumor Data

List all tumor models in MMHCdb carrying Serpinb5^tm1.2Shsh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpinb5 Mutation: 35 strains or lines available

References

• Original: J:239395 Dzinic SH, et al., An Essential Role of Maspin in Embryogenesis and Tumor Suppression. Cancer Res. 2017 Feb 15;77(4):886-896
• All: 1 reference(s)