Kera^{tm2.1(rtTA)Cyl}
Targeted Allele Detail

Summary

• Symbol: Kera^{tm2.1(rtTA)Cyl}
• Name: keratocan; targeted mutation 2.1, Chia-Yang Liu
• MGI ID: MGI:6119667
• Synonyms: Kera^RT
• Gene: Kera Location: Chr10:97442873-97449555 bp, + strand Genetic Position: Chr10, 50.34 cM
• Alliance: Kera^{tm2.1(rtTA)Cyl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:257118
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (No functional change, Transactivator)
• Mutation: Insertion
• Mutation details: An IRES-rtTA3 cassette and an FTR flanked inverted pgk-neo cassette were inserted in exon 3 immediately after the stop codon. Flp-mediated recombination removed the neo cassette. (J:257118)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kera Mutation: 30 strains or lines available

References

• Original: J:257118 Zhang Y, et al., Generation and Characterization of a Novel Mouse Line, Keratocan-rtTA (KeraRT), for Corneal Stroma and Tendon Research. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4800-4808
• All: 5 reference(s)