Gt(ROSA)26Sor^{tm1(CAG-Il11)Cook}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-Il11)Cook}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Stuart A Cook
• MGI ID: MGI:6119573
• Synonyms: Rosa26-Il11
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-Il11)Cook} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250268
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-Il11)Cook} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il11 (MGI:107613)

• Mutation details: A construct containing mouse Il11 cDNA under the control of the ubiquitous cytomegalovirus immediate early enhancer and the chicken beta-actin promoter and a loxP-flanked STOP cassette between the promoter and the cDNA was inserted into the locus. Overexpression can be conditionally induced by Cre recombinase which removes the STOP cassette. (J:250268)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:250268 Schafer S, et al., IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017 Dec 7;552(7683):110-115
• All: 5 reference(s)