Hprt1^{tm12(tetO-Vegfa*)Aird}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm12(tetO-Vegfa*)Aird}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 12, William C Aird
• MGI ID: MGI:6119550
• Synonyms: TRE-VEGFA
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm12(tetO-Vegfa*)Aird} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247085
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Hprt1^{tm12(tetO-Vegfa*)Aird} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Vegfa (MGI:103178)	VEGFA120 pro-peptide

• Mutation details: The targeting construct introduced into the locus a cDNA for the muring Vegfa 120 pro-peptide driven by a tetracylcine responsive element. (J:247085)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:247085 Rowe GC, et al., PGC-1alpha induces SPP1 to activate macrophages and orchestrate functional angiogenesis in skeletal muscle. Circ Res. 2014 Aug 15;115(5):504-17
• All: 1 reference(s)