Aspm^tm1Caw
Targeted Allele Detail

Summary

• Symbol: Aspm^tm1Caw
• Name: abnormal spindle microtubule assembly; targeted mutation 1, Christopher A Walsh
• MGI ID: MGI:6119524
• Gene: Aspm Location: Chr1:139382510-139421829 bp, + strand Genetic Position: Chr1, 61.45 cM, cytoband F
• Alliance: Aspm^tm1Caw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250399
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 1-3. Western blot analysis confirmed loss of full-length protein. (J:250399)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aspm Mutation: 138 strains or lines available

References

• Original: J:250399 Jayaraman D, et al., Microcephaly Proteins Wdr62 and Aspm Define a Mother Centriole Complex Regulating Centriole Biogenesis, Apical Complex, and Cell Fate. Neuron. 2016 Nov 23;92(4):813-828
• All: 1 reference(s)