Ptgs1^{tm2.1(Ptgs2)Fun}
Targeted Allele Detail

Summary

• Symbol: Ptgs1^{tm2.1(Ptgs2)Fun}
• Name: prostaglandin-endoperoxide synthase 1; targeted mutation 2.1, Colin D Funk
• MGI ID: MGI:6119506
• Synonyms: COX-2>COX-1, Ptgs2>Ptgs1
• Gene: Ptgs1 Location: Chr2:36120438-36142284 bp, + strand Genetic Position: Chr2, 24.19 cM
• Alliance: Ptgs1^{tm2.1(Ptgs2)Fun} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256419
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Undefined
• Ptgs1^{tm2.1(Ptgs2)Fun} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Ptgs2

• Mutation details: The genomic region containing exons 3-10 was replaced with a Ptgs2 gene fragment containing exons 2-10 and a floxed neo cassette. Cre mediated recombination removed the neo cassette. qPCR analysis confirmed the expression of a fused Ptgs1-Ptgs2 transcript in multiple tissues. (J:256419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptgs1 Mutation: 45 strains or lines available

References

• Original: J:256419 Li X, et al., Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions. J Lipid Res. 2018 Jan;59(1):89-101
• All: 3 reference(s)