Hsd11b1^tm1.1Arte
Targeted Allele Detail

Summary

• Symbol: Hsd11b1^tm1.1Arte
• Name: hydroxysteroid 11-beta dehydrogenase 1; targeted mutation 1.1, TaconicArtemis
• MGI ID: MGI:6118936
• Synonyms: Hsd11b1^del
• Gene: Hsd11b1 Location: Chr1:192903917-192946345 bp, - strand Genetic Position: Chr1, 97.67 cM
• Alliance: Hsd11b1^tm1.1Arte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256655
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Out-of-frame exon 3 was flanked by loxP sites. Cre mediated recombination removed exon 3 creating a null allele. (J:256655)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsd11b1 Mutation: 28 strains or lines available

References

• Original: J:256655 Verma M, et al., 11beta-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation. Brain Behav Immun. 2018 Mar;69:223-234
• All: 3 reference(s)