Ucp1^m1Hhz
Spontaneous Allele Detail

Summary

• Symbol: Ucp1^m1Hhz
• Name: uncoupling protein 1 (mitochondrial, proton carrier); mutation 1, Herbert Herzog
• MGI ID: MGI:6118913
• Gene: Ucp1 Location: Chr8:84016981-84025081 bp, + strand Genetic Position: Chr8, 39.65 cM
• Alliance: Ucp1^m1Hhz page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A spontaneous point mutation resulted in a C-to-A substitution at position 39 in exon 5. This mutation produces an alternative CAG splice acceptor site from CCG, the use of which results in the deletion of the first 39 nucleotides of exon 5 and 13 amino acids from the encoded peptide. Western blot analysis confirmed the absence of protein expression in brown adipose tissue from homozygous mice. (J:256980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ucp1 Mutation: 51 strains or lines available

Notes

This mutation arose in mice originally created using Bruce4 ES cells (B6.Cg-Thy1^a)

References

• Original: J:256980 Nguyen AD, et al., Uncoupling protein-1 is protective of bone mass under mild cold stress conditions. Bone. 2018 Jan;106:167-178
• All: 2 reference(s)