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Endonuclease-mediated Allele Detail
Symbol: H2-D1em4Dvs
Name: histocompatibility 2, D region locus 1; endonuclease-mediated mutation 4, David V Serreze
MGI ID: MGI:6118903
Synonyms: H2-D-
Gene: H2-D1  Location: Chr17:35482070-35486473 bp, + strand  Genetic Position: Chr17, 18.61 cM
Alliance: H2-D1em4Dvs page
Strain of Origin:  NOD/ShiLtDvs
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis endonuclease-mediated single nucleotide deletion of T in exon 2 is predicted to produce an early stop codon and flow cytometry proved the absence of H2-D1b (J:257229)
Inheritance:    Not Specified
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any H2-D1 Mutation:  37 strains or lines available
Original:  J:257229 Racine JJ, et al., Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development. Diabetes. 2018 May;67(5):923-935
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory