Opn4^{tm3.1(DTA)Saha}
Targeted Allele Detail

Summary

• Symbol: Opn4^{tm3.1(DTA)Saha}
• Name: opsin 4 (melanopsin); targeted mutation 3.1, Samer Hattar
• MGI ID: MGI:6118195
• Synonyms: Opn4^DTA
• Gene: Opn4 Location: Chr14:34312575-34322099 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
• Alliance: Opn4^{tm3.1(DTA)Saha} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256669
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-9 were replaced with a construct containing a diphtheria toxin A gene, IRES, tau-lacZ gene, and self-excising neo cassette. Cre-mediated recombination removed the neo cassette. (J:256669)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Opn4 Mutation: 34 strains or lines available

References

• Original: J:256669 Chew KS, et al., A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice. Elife. 2017 Jun 15;6:e22861
• All: 5 reference(s)