Mlkl^em1Xidw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mlkl^em1Xidw
• Name: mixed lineage kinase domain-like; endonuclease-mediated mutation 1, Xiaodong Wang
• MGI ID: MGI:6118194
• Gene: Mlkl Location: Chr8:112038429-112064809 bp, - strand Genetic Position: Chr8, 57.98 cM, cytoband D3
• Alliance: Mlkl^em1Xidw page

Mutation origin

• Strain of Origin: C57BL/6NCrl

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• An 8 bp deletion in exon 3 was created. (J:256680)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mlkl Mutation: 34 strains or lines available

References

• Original: J:256680 Li D, et al., RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. Elife. 2017 Aug 15;6:e27692
• All: 6 reference(s)