Mgp^{tm1.1(cre)Borr}
Targeted Allele Detail

Summary

• Symbol: Mgp^{tm1.1(cre)Borr}
• Name: matrix Gla protein; targeted mutation 1.1, Teresa Borras
• MGI ID: MGI:6117343
• Synonyms: Mgp-Cre
• Gene: Mgp Location: Chr6:136849433-136852821 bp, - strand Genetic Position: Chr6, 66.72 cM
• Alliance: Mgp^{tm1.1(cre)Borr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230973
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Mgp^{tm1.1(cre)Borr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mgp (MGI:96976)

• Mutation details: The targeting vector was generated by inserting IRES-Cre-FRT-flanked PGK-Neo into BAC RP23-108P5 clone containing mouse Mgp DNA fragment of 8.3 kb following endogenous stop codon. Targeted construct was introduced into ES cells to generate chimera founders. Resulting positive offspring were crossed with a flp deleter line to excise the neomycin resistance gene. (J:230973)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mgp (mouse) Summary of all recombinase alleles driven by Mgp. Comparative matrix view of recombinase activities Alliance mouse Mgp gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mgp Mutation: 10 strains or lines available

References

• Original: J:230973 Borras T, et al., A Novel Mgp-Cre Knock-In Mouse Reveals an Anticalcification/Antistiffness Candidate Gene in the Trabecular Meshwork and Peripapillary Scleral Region. Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2203-14
• All: 4 reference(s)