Sirt6^tm1.1Rmo
Targeted Allele Detail

Summary

• Symbol: Sirt6^tm1.1Rmo
• Name: sirtuin 6; targeted mutation 1.1, Raul Mostoslavsky
• MGI ID: MGI:6117342
• Synonyms: SIRT6^fl
• Gene: Sirt6 Location: Chr10:81457621-81463631 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Sirt6^tm1.1Rmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219058
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by two loxP sites and a neo cassette flanked by two FRT sites was inserted after the first loxP site. Flpe-mediated recombination removed the neo cassette leaving exon 2 floxed. (J:219058)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sirt6 Mutation: 38 strains or lines available

References

• Original: J:219058 Sebastian C, et al., The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism. Cell. 2012 Dec 7;151(6):1185-99
• All: 6 reference(s)