Tg(Myl1-rtTA2S*M2)1Lach
Transgene Detail

Summary

• Symbol: Tg(Myl1-rtTA2S*M2)1Lach
• Name: transgene insertion 1, Lewis A Chodosh
• MGI ID: MGI:6117323
• Synonyms: MDAFrtTA
• Transgene: Tg(Myl1-rtTA2S*M2)1Lach Location: unknown
• Alliance: Tg(Myl1-rtTA2S*M2)1Lach page

Transgene origin

• Strain of Origin: C57BL/6 x DBA

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The modified reverse tetracycline transactivator (rtTA) with an increased doxycycline sensitivity and lower basal activity (rtTA2S-M2) is expressed under the control of the rat myosin light chain 1 gene promoter and MLC1/3 enhancer. Expression is seen in skeletal muscle. Two lines were generated, with one studied further. (J:106884)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:106884 Ponomareva ON, et al., Defective neuromuscular synaptogenesis in mice expressing constitutively active ErbB2 in skeletal muscle fibers. Mol Cell Neurosci. 2006 Feb;31(2):334-45
• All: 5 reference(s)