Gt(ROSA)26Sor^{tm1(Rspo1)Mcch}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(Rspo1)Mcch}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Marie-Christine Chaboissier
• MGI ID: MGI:6117130
• Synonyms: R26^Rspo1
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(Rspo1)Mcch} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237958
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(Rspo1)Mcch} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Rspo1

• Mutation details: The targeting construct inserted into the locus a floxed PGK-neo STOP cassette and the mouse R-spondin 1 cDNA. Cre-induced recombination results in excision of the STOP cassette and expression of the cDNA. (J:237958)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:237958 De Cian MC, et al., Amplification of R-spondin1 signaling induces granulosa cell fate defects and cancers in mouse adult ovary. Oncogene. 2017 Jan 12;36(2):208-218
• All: 2 reference(s)