Sst^{tm1.1(cre)Mony}
Targeted Allele Detail

Summary

• Symbol: Sst^{tm1.1(cre)Mony}
• Name: somatostatin; targeted mutation 1.1, Hannah Monyer
• MGI ID: MGI:6116825
• Synonyms: SOM^Cre
• Gene: Sst Location: Chr16:23708323-23709708 bp, - strand Genetic Position: Chr16, 15.0 cM, cytoband cen-C3
• Alliance: Sst^{tm1.1(cre)Mony} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252090
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Sst^{tm1.1(cre)Mony} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sst (MGI:98326)

• Mutation details: A Cre recombinase cassette followed by a neomycin cassette flanked by two frt sites was introduced 30 bp upstream of the translational start codon in exon 1 of the murine SOM gene. The neomycin selection cassette was removed by FLP-mediated recombination. (J:252090)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sst (mouse) Summary of all recombinase alleles driven by Sst. Comparative matrix view of recombinase activities Alliance mouse Sst gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sst Mutation: 35 strains or lines available

References

• Original: J:252090 Melzer S, et al., Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex. Science. 2012 Mar 23;335(6075):1506-10
• All: 3 reference(s)