Apoe^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Apoe^tm1.1Geno
• Name: apolipoprotein E; targeted mutation 1, Genoway
• MGI ID: MGI:6116821
• Synonyms: Apoe^loxP
• Gene: Apoe Location: Chr7:19430034-19433113 bp, - strand Genetic Position: Chr7, 9.94 cM
• Alliance: Apoe^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244287
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Two loxP sites were inserted flanking exons 2 to 4. A neomycin selection cassette flanked by FRT sites was removed by FLP-mediated recombination. (J:244287)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apoe Mutation: 168 strains or lines available

References

• Original: J:244287 Wagner T, et al., Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity. PLoS One. 2015;10(12):e0145102
• All: 3 reference(s)