Dync2i2^tm1Blnw
Targeted Allele Detail

Summary

• Symbol: Dync2i2^tm1Blnw
• Name: dynein 2 intermediate chain 2; targeted mutation 1, Baolin Wang
• MGI ID: MGI:6116689
• Synonyms: Wdr34^-
• Gene: Dync2i2 Location: Chr2:29921563-29938891 bp, - strand Genetic Position: Chr2, 21.04 cM
• Alliance: Dync2i2^tm1Blnw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:242833
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-8, covering most of the coding region, were replaced with a neomycin cassette flanked by loxP sites. This deletion is expected to cause an open reading frame shift, most likely resulting in a null allele. (J:242833)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dync2i2 Mutation: 58 strains or lines available

References

• Original: J:242833 Wu C, et al., Loss of dynein-2 intermediate chain Wdr34 results in defects in retrograde ciliary protein trafficking and Hedgehog signaling in the mouse. Hum Mol Genet. 2017 Jul 01;26(13):2386-2397
• All: 1 reference(s)