Mstn^tm1.1Thbr
Targeted Allele Detail

Summary

• Symbol: Mstn^tm1.1Thbr
• Name: myostatin; targeted mutation 1.1, Thomas Braun
• MGI ID: MGI:6116685
• Synonyms: Mstn^fl
• Gene: Mstn Location: Chr1:53100799-53107238 bp, + strand Genetic Position: Chr1, 26.99 cM
• Alliance: Mstn^tm1.1Thbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:247083
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Insertion of loxP elements upstream and downstream of exons 1 and 2 of the gene. A neomycin selection cassette was removed by FLP-mediated recombination. (J:247083)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mstn Mutation: 38 strains or lines available

References

• Original: J:247083 Biesemann N, et al., Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circ Res. 2014 Jul 07;115(2):296-310
• All: 3 reference(s)