Tg(Or10j5-Or6a2*,-ECFP)1Hsak
Transgene Detail
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Symbol: |
Tg(Or10j5-Or6a2*,-ECFP)1Hsak |
Name: |
transgene insertion 1, Hitoshi Sakano |
MGI ID: |
MGI:6116457 |
Synonyms: |
I7-ires-gap-CFP, I7(WT)-IRES-ECFP, l7(WT), Tg(Olfr16-Olr226,-ECFP)1Hsak |
Transgene: |
Tg(Or10j5-Or6a2*,-ECFP)1Hsak Location: unknown
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Alliance: |
Tg(Or10j5-Or6a2*,-ECFP)1Hsak page
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Transgene Type: |
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Transgenic (Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Mutation details: This transgene puts the rat Olfr2 gene under the control of the mouse Olfr226 promoter. In the rat Olfr2 gene, the DRY motif at the cytoplasmic end of the transmembrane domain III was mutated to RDY. It was predicted this mutation would prevent association of G proteins involved in downstream signaling. An enhanced cyan fluorescent protein (CFP) reporter gene was also inserted downstream of the rat gene.
(J:128070)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Original: |
J:128070 Imai T, et al., Odorant receptor-derived cAMP signals direct axonal targeting. Science. 2006 Oct 27;314(5799):657-61 |
All: |
4 reference(s) |
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