Sh2d3c^tm1Kale
Targeted Allele Detail

Summary

• Symbol: Sh2d3c^tm1Kale
• Name: SH2 domain containing 3C; targeted mutation 1, Konstantina Alexandropoulos
• MGI ID: MGI:6115874
• Synonyms: Chat^fl
• Gene: Sh2d3c Location: Chr2:32611072-32645008 bp, + strand Genetic Position: Chr2, 22.09 cM, cytoband B
• Alliance: Sh2d3c^tm1Kale page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246144
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 6. A floxed neomycin resistance cassette was inserted downstream of exon 6. (J:246144)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d3c Mutation: 31 strains or lines available

References

• Original: J:246144 Herbin O, et al., Monocyte Adhesion and Plaque Recruitment During Atherosclerosis Development Is Regulated by the Adapter Protein Chat-H/SHEP1. Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1791-801
• All: 1 reference(s)