Igk-J^tm3.1Lave
Targeted Allele Detail

Summary

• Symbol: Igk-J^tm3.1Lave
• Name: immunoglobulin kappa chain, joining region; targeted mutation 3.1, Laurent Verkoczy
• MGI ID: MGI:6115820
• Synonyms: CH103 UCA VkappaJkappa
• Gene: Igk-J Location: unknown Genetic Position: Chr6, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256269
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced the first two exons of the J region with a floxed neomycin resistance cassette, VkappaOx1 promoter, a VkappaOx1 split leader, and the CH103 unmutated common ancestor VkappaJkappa rearrangement. Cre-mediated recombination removed the selection cassette. (J:256269)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igk-J Mutation: 9 strains or lines available

References

• Original: J:256269 Williams WB, et al., Initiation of HIV neutralizing B cell lineages with sequential envelope immunizations. Nat Commun. 2017 Nov 23;8(1):1732
• All: 1 reference(s)