Gt(ROSA)26Sor^{tm2(CAG-mCherry,-CD320,-RABVgp4)Ylu}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(CAG-mCherry,-CD320,-RABVgp4)Ylu}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Youming Lu
• MGI ID: MGI:6115793
• Synonyms: TVA/G^loxP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(CAG-mCherry,-CD320,-RABVgp4)Ylu} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256568
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector inserted into the locus a CAG (CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter), FRT site, loxP-flanked STOP cassette, FLAG-tagged avian viral receptor TVA (CD320) and rabies G protein (RAGVgp4), mCherry reporter gene, WPRE (to enhance the mRNA transcript stability), a poly-A signal and an attB/att-flanked PGK-FRT-Neo-poly-A cassette. (J:256568)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:256568 Yang X, et al., A novel mechanism of memory loss in Alzheimer's disease mice via the degeneration of entorhinal-CA1 synapses. Mol Psychiatry. 2018 Feb;23(2):199-210
• All: 2 reference(s)