Plekhm2^{tm1b(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Plekhm2^{tm1b(EUCOMM)Wtsi}
• Name: pleckstrin homology domain containing, family M (with RUN domain) member 2; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6115604
• Gene: Plekhm2 Location: Chr4:141353043-141391457 bp, - strand Genetic Position: Chr4, 74.64 cM
• Alliance: Plekhm2^{tm1b(EUCOMM)Wtsi} page
• IMPC: Plekhm2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:256313
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The L1L2_gt1 cassette was inserted at position 141361279 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 141362264. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). (J:256313)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plekhm2 Mutation: 48 strains or lines available

References

• Original: J:256313 Saitoh SI, et al., TLR7 mediated viral recognition results in focal type I interferon secretion by dendritic cells. Nat Commun. 2017 Nov 17;8(1):1592
• All: 1 reference(s)