Hdac11^tm1.1Mrl
Targeted Allele Detail

Summary

• Symbol: Hdac11^tm1.1Mrl
• Name: histone deacetylase 11; targeted mutation 1.1, Merck Research Laboratory
• MGI ID: MGI:6115541
• Gene: Hdac11 Location: Chr6:91133652-91151674 bp, + strand Genetic Position: Chr6, 40.38 cM
• Alliance: Hdac11^tm1.1Mrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:245003
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 3 was floxed by loxP sites and a frt-flanked selection cassette was inserted dowstream of exon 3. Flp-mediated recombination removed the selection cassette. (J:245003)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac11 Mutation: 21 strains or lines available

References

• Original: J:245003 Woods DM, et al., T cells lacking HDAC11 have increased effector functions and mediate enhanced alloreactivity in a murine model. Blood. 2017 Jul 13;130(2):146-155
• All: 4 reference(s)