Xirp2^{tm1b(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Xirp2^{tm1b(KOMP)Wtsi}
• Name: xin actin-binding repeat containing 2; targeted mutation 1b, Wellcome Trust Sanger Institute
• MGI ID: MGI:6115345
• Synonyms: Xirp2^lacZtm2
• Gene: Xirp2 Location: Chr2:67276343-67356964 bp, + strand Genetic Position: Chr2, 39.31 cM
• Alliance: Xirp2^{tm1b(KOMP)Wtsi} page
• IMPC: Xirp2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255706
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Intragenic deletion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 67334957 of Chromosome 2 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 67336151. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by cre recombinase expression in mice carrying the tm1a allele to remove the neo selection cassette and loxP-flanked critical exon(s). (J:255706)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xirp2 Mutation: 163 strains or lines available

References

• Original: J:255706 Huang L, et al., Critical Roles of Xirp Proteins in Cardiac Conduction and Their Rare Variants Identified in Sudden Unexplained Nocturnal Death Syndrome and Brugada Syndrome in Chinese Han Population. J Am Heart Assoc. 2018 Jan 6;7(1)
• All: 1 reference(s)