Yap1^tm1.1Stang
Targeted Allele Detail

Summary

• Symbol: Yap1^tm1.1Stang
• Name: yes-associated protein 1; targeted mutation 1.1, Ben Stanger
• MGI ID: MGI:6115258
• Synonyms: YAP^het
• Gene: Yap1 Location: Chr9:7932000-8004597 bp, - strand Genetic Position: Chr9, 2.46 cM
• Alliance: Yap1^tm1.1Stang page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:255620
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Hypomorph, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting construct contains an FRT-flanked PGK-neomycin cassette, followed by loxP sites flanking the 5' UTR and the first intron. Flp-mediated recombination removed the FRT-flanked neo cassette. The authors note that the allele is null or severely hypomorphic based on embryonic lethality in homozygotes. (J:255620)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Yap1 Mutation: 40 strains or lines available

References

• Original: J:255620 Gao T, et al., Hippo signaling regulates differentiation and maintenance in the exocrine pancreas. Gastroenterology. 2013 Jun;144(7):1543-53, 1553.e1
• All: 1 reference(s)