Gli2^tm4.1Blnw
Targeted Allele Detail

Summary

• Symbol: Gli2^tm4.1Blnw
• Name: GLI-Kruppel family member GLI2; targeted mutation 4.1, Baolin Wang
• MGI ID: MGI:6114979
• Synonyms: Gli2^FLAGki
• Gene: Gli2 Location: Chr1:118761862-118981349 bp, - strand Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
• Alliance: Gli2^tm4.1Blnw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:248981
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Epitope tag)
• Mutation: Insertion
• Mutation details: A triple flag tag and neomycin resistance cassette were inserted after the first exon. Cre-mediated recombination removed the selection cassette. (J:248981)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gli2 Mutation: 173 strains or lines available

References

• Original: J:248981 Li J, et al., PKA-mediated Gli2 and Gli3 phosphorylation is inhibited by Hedgehog signaling in cilia and reduced in Talpid3 mutant. Dev Biol. 2017 Sep 1;429(1):147-157
• All: 1 reference(s)