Casp8^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Casp8^m1Btlr
• Name: caspase 8; mutation 1, Bruce Beutler
• MGI ID: MGI:6113870
• Synonyms: amontillado
• Gene: Casp8 Location: Chr1:58834533-58886662 bp, + strand Genetic Position: Chr1, 29.19 cM, cytoband B
• Alliance: Casp8^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: ENU-induced T to C transition at base pair 58,844,770 (GRCm38) on chromosome 1, or base pair 49,543 in the GenBank genomic region NC_000067 encoding caspase-8. The mutation corresponds to residue 1,628 in the mRNA sequence NM_009812, within 8 of 9 exons. The mutation results in a valine to alanine substitution at position 432 (V432A) in isoform 1. (J:255007)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp8 Mutation: 42 strains or lines available

References

• Original: J:255007 Zeng M, et al., Mutagenetix entry for amontillado. MGI Direct Data Submission. 2018
• All: 1 reference(s)