Slc1a5^tm1Tac
Targeted Allele Detail

Summary

• Symbol: Slc1a5^tm1Tac
• Name: solute carrier family 1 (neutral amino acid transporter), member 5; targeted mutation 1, Taconic
• MGI ID: MGI:6113803
• Gene: Slc1a5 Location: Chr7:16515265-16532199 bp, + strand Genetic Position: Chr7, 9.15 cM, cytoband A2
• Alliance: Slc1a5^tm1Tac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254980
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neomycin resistance cassette replaced exons 2 through 4. RT-PCR confirmed the absence of transcript expression. (J:254980)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc1a5 Mutation: 23 strains or lines available

References

• Original: J:254980 Nakaya M, et al., Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity. 2014 May 15;40(5):692-705
• All: 2 reference(s)