Tg(Mrc1-HBEGF)#Yuha
Transgene Detail

Summary

• Symbol: Tg(Mrc1-HBEGF)#Yuha
• Name: transgene insertion, Yuich Hatori
• MGI ID: MGI:6113802
• Synonyms: CD206DTR, CD206^{DT receptor}
• Transgene: Tg(Mrc1-HBEGF)#Yuha Location: unknown
• Alliance: Tg(Mrc1-HBEGF)#Yuha page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Mrc1-HBEGF)#Yuha expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The 152 kb BAC clone (RP24-377D19) containing the exon coding traslational start codon and upstream 133 kb sequence of mouse Mrc1 (CD206) gene was modified by introducing noncoding exon and intron from rabbit b-globulin gene, human HB-EGF (DT receptor) cDNA, and rabbit b-globulin and simian virus 40 polyadenylation (pA) signals into the BAC. Line numbers were not indicated. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:216955)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:216955 Kambara K, et al., In Vivo Depletion of CD206(+) M2 Macrophages Exaggerates Lung Injury in Endotoxemic Mice. Am J Pathol. 2015 Jan;185(1):162-71
• All: 6 reference(s)