Ptprc^m3Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptprc^m3Btlr
• Name: protein tyrosine phosphatase receptor type C; mutation 3, Bruce Beutler
• MGI ID: MGI:6113595
• Synonyms: guotie2
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^m3Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: ENU treatment induced a T-to-C transition at base pair 138,094,299 (GRCm38) on chromosome 1, or base pair 76,276 in the GenBank genomic region NC_000067. The mutation corresponds to residue 1,669 in the mRNA sequence NM_001111316 within exon 15 of 33 total exons, residue 1,350 in the mRNA sequence NM_011210 within exon 12 of 30 total exons, and residue 1,278 in the mRNA sequence NM_001268286 within exon 11 of 29 total exons. The mutation results in a serine (S) to proline (P) substitution at position 544 (p.S544P) in variant 1 of the PTPRC protein, a p.S405P substitution in variant 2, and a p.S381P substitution in variant 3. (J:254899)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 212 strains or lines available

References

• Original: J:254899 Zhong X, et al., Mutagenetix entry for guotie2. MGI Direct Data Submission. 2018
• All: 1 reference(s)