Pik3r1^M2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Pik3r1^M2Btlr
• Name: phosphoinositide-3-kinase regulatory subunit 1; mutation 2, Bruce Beutler
• MGI ID: MGI:6113585
• Synonyms: Rocket
• Gene: Pik3r1 Location: Chr13:101817269-101904725 bp, - strand Genetic Position: Chr13, 53.92 cM
• Alliance: Pik3r1^M2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Modified isoform(s))
• Mutation: Single point mutation
• Mutation details: ENU-induced G to A transition at base pair 101,689,444 (v38) on chromosome 13, or base pair 78,774 in the GenBank genomic region NC_000079. The mutation corresponds to residue 1,694 in the mRNA sequence NM_001077495 within exon 9 of 16 total exons and to residue 605 in the mRNA sequence NM_001024955 within exon 3 of 10 total exons. The mutation results in an arginine to glutamine substitution at residue 358 (R358Q) in the p85alpha protein as well as an R88Q substitution in p55alpha and p50alpha. (J:254892)
• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3r1 Mutation: 55 strains or lines available

Notes

Inheritance is unknown/not applicable.

References

• Original: J:254892 Zhong X, et al., Mutagenetix entry for Rocket. MGI Direct Data Submission. 2018
• All: 1 reference(s)