Trp53bp1^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Trp53bp1^m2Btlr
• Name: transformation related protein 53 binding protein 1; mutation 2, Bruce Beutler
• MGI ID: MGI:6113484
• Synonyms: lentil2
• Gene: Trp53bp1 Location: Chr2:121023762-121101888 bp, - strand Genetic Position: Chr2, 60.37 cM
• Alliance: Trp53bp1^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: ENU-induced C-to-A transversion at base pair 121,207,887 (GRCm38) on chromosome 2, or base pair 82,439 in the GenBank genomic region NC_000068. The mutation corresponds to residue 4,448 in the mRNA sequence NM_001290830 within exon 20 of 27 total exons and residue 4,598 in the mRNA sequence NM_013735 within exon 21 of 28 total exons. The mutation results in an alanine (A) to aspartic acid (D) substitution at position 1440 (p.A1440D) in the protein. (J:254841)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53bp1 Mutation: 100 strains or lines available

References

• Original: J:254841 Choi JH, et al., Mutagenetix entry for lentil2. MGI Direct Data Submission. 2018
• All: 1 reference(s)