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Targeted Allele Detail
Symbol: Kiss1tm2(cre/GFP)Coll
Name: KiSS-1 metastasis-suppressor; targeted mutation 2, William H Colledge
MGI ID: MGI:6113450
Synonyms: Kiss1-Cre:GFP, Kiss1CRE-GFP, Kiss1tm2(Cre-GFP)Coll
Gene: Kiss1  Location: Chr1:133254950-133257460 bp, + strand  Genetic Position: Chr1, 57.91 cM
Alliance: Kiss1tm2(cre/GFP)Coll page
Germline Transmission:  Earliest citation of germline transmission: J:254977
Parent Cell Line:  CCB (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout, Recombinase, Reporter)
Mutations:    Insertion, Intragenic deletion
Kiss1tm2(cre/GFP)Coll expression driven by 1 gene
Mutation detailsA targeting vector was designed to insert the cre/GFP fusion gene with a neo cassette in exon 2 of the mouse Kiss1 gene such that ATG of the cre/GFP fusion gene was kept in frame located 11 codons downstream of the Kiss1 ATG. The absence of protein was confirmed in mutant mice. (J:254977)
 Tissue activity of this recombinase allele
Driver: Kiss1 (mouse)
Summary of all recombinase alleles driven by Kiss1.

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Kiss1 Mutation:  22 strains or lines available
Original:  J:254977 Yeo SH, et al., Visualisation of Kiss1 Neurone Distribution Using a Kiss1-CRE Transgenic Mouse. J Neuroendocrinol. 2016 Nov;28(11)
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory