Krastm5(Hras*G12V)Bbd
Targeted Allele Detail
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Symbol: |
Krastm5(Hras*G12V)Bbd |
Name: |
Kirsten rat sarcoma viral oncogene homolog; targeted mutation 5, Mariano Barbacid |
MGI ID: |
MGI:6111952 |
Synonyms: |
KHRasV12, K-RasLSLH-RasG12V |
Gene: |
Kras Location: Chr6:145162425-145195965 bp, - strand Genetic Position: Chr6, 77.37 cM, cytoband G2
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Alliance: |
Krastm5(Hras*G12V)Bbd page
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence, Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Krastm5(Hras*G12V)Bbd expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Hras (MGI:96224) |
Codon 12 contains a Gly to Val mutation. |
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Mutation details: Murine Hras cDNA with glycine codon 12 (GGA) changed to valine (GTA) (p.G12V) was knocked in replacing the coding region of exon 2. The Hras cDNA is preceded by an Lox-STOP-Lox cassette.
(J:239406)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kras Mutation: |
76 strains or lines available
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Original: |
J:239406 Drosten M, et al., H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences. Cancer Res. 2017 Feb 01;77(3):707-718 |
All: |
1 reference(s) |
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