Gabbr1^tm1Aztc
Targeted Allele Detail

Summary

• Symbol: Gabbr1^tm1Aztc
• Name: gamma-aminobutyric acid type B receptor subunit 1; targeted mutation 1, Astrazeneca Transgenic Center
• MGI ID: MGI:6111938
• Synonyms: GABAB(1)^-
• Gene: Gabbr1 Location: Chr17:37356888-37385197 bp, + strand Genetic Position: Chr17, 19.16 cM
• Alliance: Gabbr1^tm1Aztc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:254530
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed gene trap cassette containing a splice acceptor and beta-geo cassette replaced exon E1a1 to the translation initiation site in E1a/b. Western blot analysis confirmed the absence of isoform 1 and expression of isoform 2. (J:254530)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabbr1 Mutation: 74 strains or lines available

References

• Original: J:254530 Queva C, et al., Effects of GABA agonists on body temperature regulation in GABA(B(1))-/- mice. Br J Pharmacol. 2003 Sep;140(2):315-22
• All: 1 reference(s)